Hypothalamic hypothyroidism was identified in a 53-year-old man. Two years before developing hypothyroidism, he manifested somnolence, transient diabetes insipidus, and altered thirst perception. Pneumoencephalograms revealed absence of the corpus callosum. Thyroid function tests disclosed decreased serum thyroxine and triiodothyronine (T3), low basal metabolic rate, and diminished thyroidal uptake of radioactive iodine (RAI). Basal thyrotropin levels were normal and rose promptly after the intravenous administration of thyrotropin releasing hormone (TRH). Basal T3 levels were low and did not rise in response to TRH although T3 level and RAI uptake rose after the intramuscular administration of thyrotropin.
|Number of pages||2|
|Journal||JAMA - Journal of the American Medical Association|
|State||Published - 23 Oct 1972|