Hypothalamic Hypothyroidism

Louis Shenkman*, Terunori Mitsuma, Araya Suphavai, Charles S. Hollander

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hypothalamic hypothyroidism was identified in a 53-year-old man. Two years before developing hypothyroidism, he manifested somnolence, transient diabetes insipidus, and altered thirst perception. Pneumoencephalograms revealed absence of the corpus callosum. Thyroid function tests disclosed decreased serum thyroxine and triiodothyronine (T3), low basal metabolic rate, and diminished thyroidal uptake of radioactive iodine (RAI). Basal thyrotropin levels were normal and rose promptly after the intravenous administration of thyrotropin releasing hormone (TRH). Basal T3 levels were low and did not rise in response to TRH although T3 level and RAI uptake rose after the intramuscular administration of thyrotropin.

Original languageEnglish
Pages (from-to)480-481
Number of pages2
JournalJAMA - Journal of the American Medical Association
Issue number4
StatePublished - 23 Oct 1972
Externally publishedYes


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