Hypofractionated adjuvant radiation therapy of soft-tissue sarcoma achieves excellent results in elderly patients

V. Soyfer, B. W. Corn, Y. Kollender, J. Issakov, S. Dadia, G. Flusser, J. Bickels, I. Meller, O. Merimsky

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Adjuvant radiation therapy (RT) is an essential part of combined limb-sparing treatment of soft-tissue sarcoma (STS). Elderly or medically unfit patients often have difficulty in completing 6-7 weeks of standard fractionated daily treatment. Our aim was to evaluate the efficacy of a hypofractionated adjuvant approach with RT for STS in elderly and debilitated patients. Methods: 21 elderly patients were treated with a short course of adjuvant RT (39-48Gy, 3Gy per fraction) for STS. The medical records of the patients were retrospectively reviewed for local or distant recurrence and side effects of RT. Results: At a mean 26 months of follow-up, three local recurrences (14%) were detected. Eight patients (38%) had lung metastases during the observed period. Three of them died from metastatic disease. The hypofractionated radiation was well tolerated with minimum long-term side effects. Conclusion: Hypofractionated adjuvant radiation appears to be an effective treatment in terms of local control in elderly and debilitated patients. Advances in knowledge: The results of this study might provide an alternative to commonly used standard fractionation of radiotherapy in sarcoma patients.

Original languageEnglish
Article number20130258
JournalBritish Journal of Radiology
Volume86
Issue number1028
DOIs
StatePublished - 1 Aug 2013
Externally publishedYes

Fingerprint

Dive into the research topics of 'Hypofractionated adjuvant radiation therapy of soft-tissue sarcoma achieves excellent results in elderly patients'. Together they form a unique fingerprint.

Cite this