Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice

Alicia Leikin-Frenkel, Paolo Parini*, Fred M. Konikoff, Lisbet Benthin, Diana Leikin-Gobbi, Ilana Goldiner, Curt Einarsson, Tuvia Gilat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Fatty acid bile acid conjugates (FABACs) prevent and dissolve cholesterol gallstones and prevent diet induced fatty liver, in mice. The present studies aimed to test their hypocholesterolemic effects in mice. Gallstone susceptible (C57L/J) mice, on high fat (HFD) or regular diet (RD), were treated with the conjugate of cholic acid with arachidic acid (FABAC; Aramchol). FABAC reduced the elevated plasma cholesterol levels induced by the HFD. In C57L/J mice, FABAC reduced plasma cholesterol by 50% (p < 0.001). In mice fed HFD, hepatic cholesterol synthesis was reduced, whereas CYP7A1 activity and expression were increased by FABAC. The ratio of fecal bile acids/neutral sterols was increased, as was the total fecal sterol excretion. In conclusion, FABACs markedly reduce elevated plasma cholesterol in mice by reducing the hepatic synthesis of cholesterol, in conjunction with an increase of its catabolism and excretion from the body.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalArchives of Biochemistry and Biophysics
Volume471
Issue number1
DOIs
StatePublished - 1 Mar 2008

Funding

FundersFunder number
Swedish Heart and Lung Foundation
Vetenskapsrådet
Sveriges Läkarförbund

    Keywords

    • Bile acid
    • Cholesterol
    • Fatty acid
    • Gallstone
    • Lipoproteins
    • Liver
    • Mice
    • Neutral sterols

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