Hypocholesterolemia in children and adolescents with β-thalassemia intermedia

Corina Hartman, Hannah Tamary, Ada Tamir, Evelyn Shabad, Carina Levine, Ariel Koren, Raanan Shamir

Research output: Contribution to journalArticlepeer-review


Objectives: To conduct a prospective study to evaluate the lipid profile in children and adolescents with β-thalassemia intermedia and major, and to examine the contribution of different factors to hypocholesterolemia observed in these patients. Study design: Demographic, clinical, and laboratory data were prospectively obtained from patients with β-thalassemia intermedia (n = 9) and major (n = 47). Lipid profiles were also determined in a control group of healthy children (n = 18). Lipid values of β-thalassemics and controls were compared and the relationships between lipid levels and different covariates were determined. Results: β-thalassemia intermedia patients had significandy lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) compared with β-thalassemia major and controls (P < .001). With regression analysis, serum lipid levels (TC, HDL-C, and triglycerides) correlated with diagnosis (β-thalassemia major or intermedia) but not with age, sex, hemoglobin, or ferritin. LDL-C was influenced by both diagnosis and ferritin levels. Conclusions: Children and adolescents with β-thalassemia intermedia have significantly lower cholesterol levels than patients with β-thalassemia major. This is related to their disorder and not influenced by age, sex, hemoglobin, or ferritin levels. In these patients, needless investigations for hypolipidemia should be avoided.

Original languageEnglish
Pages (from-to)543-547
Number of pages5
JournalJournal of Pediatrics
Issue number4
StatePublished - 1 Oct 2002


Dive into the research topics of 'Hypocholesterolemia in children and adolescents with β-thalassemia intermedia'. Together they form a unique fingerprint.

Cite this