Hypertrophic pulmonary osteoarthropathy: Control of pain and symptoms with pamidronate

Howard Amital*, Yaakov H. Applbaum, Lena Vasiliev, Alan Rubinow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


This case presents a patient with hypertrophic osteoarthropathy of the lower extremities that developed secondary to congenital cyanotic heart disease. The major clinical manifestation was severe bilateral leg pain. The pain that was debilitating in nature completely resolved following a single administration of 60 mg pamidronate. Hypertrophic osteoarthropathy (HOA) is an acquired, uncommon disorder of obscure etiology. It has been described mainly in association with chronic suppurative pulmonary diseases, bronchogenic carcinoma and lung metastases, cystic fibrosis, and cyanotic congenital malformations of the heart.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalClinical Rheumatology
Issue number4
StatePublished - Aug 2004
Externally publishedYes


  • Bisphosphonates
  • Cyanotic heart disease
  • Hypertrophic pulmonary osteoarthropathy
  • Pain
  • Pamidronate


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