Hyperthyroidism After Propranolol Withdrawal

Louis Shenkman; Jerome Lowenstein; Philip Podrid

doi:10.1001/jama.1977.03280030045021

Hyperthyroidism After Propranolol Withdrawal

Louis Shenkman, Jerome Lowenstein, Philip Podrid

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Abstract

Classic features of thyrotoxicosis developed in three patients with no prior history of thyroid disease shortly after the discontinuation of therapy with or decrease in dosage of propranolol hydrochloride. Graves' disease probably developed fortuitously after propranolol therapy was instituted, but the β-adrenergic blockade masked the clinical features of hyperthyroidism. On discontinuation of propranolol therapy or decrease in propranolol dosage, previously latent thyrotoxicosis became manifest. If hyperthyroidism masked by β-blockade is not recognized before withdrawal of propranolol therapy in patients with ischemic heart disease, the sudden appearance of thyrotoxicosis may lead to symptoms of increased myocardial ischemia. (JAMA 238:237-239, 1977).

Original language	English
Pages (from-to)	237-239
Number of pages	3
Journal	JAMA - Journal of the American Medical Association
Volume	238
Issue number	3
DOIs	https://doi.org/10.1001/jama.1977.03280030045021
State	Published - 18 Jul 1977
Externally published	Yes

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10.1001/jama.1977.03280030045021

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title = "Hyperthyroidism After Propranolol Withdrawal",

abstract = "Classic features of thyrotoxicosis developed in three patients with no prior history of thyroid disease shortly after the discontinuation of therapy with or decrease in dosage of propranolol hydrochloride. Graves' disease probably developed fortuitously after propranolol therapy was instituted, but the β-adrenergic blockade masked the clinical features of hyperthyroidism. On discontinuation of propranolol therapy or decrease in propranolol dosage, previously latent thyrotoxicosis became manifest. If hyperthyroidism masked by β-blockade is not recognized before withdrawal of propranolol therapy in patients with ischemic heart disease, the sudden appearance of thyrotoxicosis may lead to symptoms of increased myocardial ischemia. (JAMA 238:237-239, 1977).",

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doi = "10.1001/jama.1977.03280030045021",

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AU - Lowenstein, Jerome

AU - Podrid, Philip

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N2 - Classic features of thyrotoxicosis developed in three patients with no prior history of thyroid disease shortly after the discontinuation of therapy with or decrease in dosage of propranolol hydrochloride. Graves' disease probably developed fortuitously after propranolol therapy was instituted, but the β-adrenergic blockade masked the clinical features of hyperthyroidism. On discontinuation of propranolol therapy or decrease in propranolol dosage, previously latent thyrotoxicosis became manifest. If hyperthyroidism masked by β-blockade is not recognized before withdrawal of propranolol therapy in patients with ischemic heart disease, the sudden appearance of thyrotoxicosis may lead to symptoms of increased myocardial ischemia. (JAMA 238:237-239, 1977).

AB - Classic features of thyrotoxicosis developed in three patients with no prior history of thyroid disease shortly after the discontinuation of therapy with or decrease in dosage of propranolol hydrochloride. Graves' disease probably developed fortuitously after propranolol therapy was instituted, but the β-adrenergic blockade masked the clinical features of hyperthyroidism. On discontinuation of propranolol therapy or decrease in propranolol dosage, previously latent thyrotoxicosis became manifest. If hyperthyroidism masked by β-blockade is not recognized before withdrawal of propranolol therapy in patients with ischemic heart disease, the sudden appearance of thyrotoxicosis may lead to symptoms of increased myocardial ischemia. (JAMA 238:237-239, 1977).

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Hyperthyroidism After Propranolol Withdrawal

Abstract

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