Hyperthermia and formaldehyde can dissociate the binding and killing activities of cytolytic T lymphocytes

In the present study, the authors investigated whether the binding and cytolytic activities of CTL are governed by the same cellular entity, a question which is fundamental to understanding the mechanism of CTL-mediated lysis. The results presented in this paper and elsewhere indicating that the CTL binding and killing activities could be differentially affected by both hyperthermia and formaldehyde, suggest that these activities are mediated by different, although closely related, cellular entities.