Hypersensitivity to paracetamol in Asian children with early onset of nonsteroidal anti-inflammatory drug allergy

Mona Iancovici Kidon*, Woei Kang Liew, Wen Chin Chiang, Siok Hoon Lim, Anne Goh, Jenny Poh Lin Tang, Oh Moh Chay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: The published incidence of paracetamol cross-reactivity in adults and adolescents with nonsteroidal anti-inflammatory drug (NSAID) reactions is low and all data on such reactions in young children is sparse. The study aim was to characterize the clinical presentation and cross-reactivity with paracetamol in patients with a reported onset of NSAID hypersensitivity before 6 years of age. Methods: A retrospective case review was done of patients with cross-reactive hypersensitivity reactions to antipyretic/analgesic medications from the pediatric allergy clinic of the Kendang Kerbau Hospital, Singapore. Included patients reported the onset of such reactions before 6 years of age. Hypersensitivity was established through a detailed history of recurrent reactions to NSAIDs or an oral provocation test. Results: Eighteen patients fulfilled the diagnostic criteria within the study period. Eighty-three percent had cross-reactive reactions with paracetamol. When compared to the group of children with later onset of NSAID hypersensitivity, children with onset before 6 years of age had a significantly increased likelihood of reacting to paracetamol (odds ratio 9.6, 95% confidence interval 1.6-58.0, p < 0.05). Conclusion: Paracetamol seems to be a major eliciting drug in this group of children.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume144
Issue number1
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • Children
  • Hypersensitivity
  • Nonsteroidal anti-inflammatory drugs
  • Paracetamol
  • Preschool

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