Hypersensitivity to mycophenolate mofetil in systemic lupus erythematosus: Diagnostic measures and successful desensitization

Martine Szyper-Kravitz, Pavel Sheinberg, Yechezkel Sidi, Yael Schiffenbauer, Ela Trubniykov, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Despite therapeutic advances in the treatment of systemic lupus erythematosus (SLE), several patients are still afflicted with severe and uncontrolled symptoms. Recently, mycophenolate mofetil (MMF) has been introduced in the treatment of SLE, with a significant therapeutic benefit, and minor side effects have been reported. Data on the adverse effects of MMF in SLE are lacking. We present an SLE patient who developed urticaria during MMF treatment. Rechallenge with MMF established the diagnosis of MMF-induced urticaria. As MMF was considered a necessary therapy, a desensitization protocol was devised, which successfully induced tolerance to MMF. This is the first published protocol for MMF desensitization, which induced tolerance in an SLE patient previously reacting with generalized urticaria.

Original languageEnglish
Pages (from-to)334-336
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume138
Issue number4
DOIs
StatePublished - Dec 2005

Keywords

  • Desensitization
  • Mycophenolate mofetil
  • Systemic lupus erythematosus

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