Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue decapeptyl in girls with central precocious puberty

A. Kauschansky; M. Nussinovitch; M. Frydman; A. Yeshaya; Z. Ben-Rafael

doi:10.1016/s0015-0282(16)57724-3

Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue decapeptyl in girls with central precocious puberty

A. Kauschansky^*, M. Nussinovitch, M. Frydman, A. Yeshaya, Z. Ben-Rafael

^*Corresponding author for this work

Schneider Childrens Medical Center Israel

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective: To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Design: Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months. Setting: Pediatric Endocrine Clinic, Hasbaron Hospital, Petah Tiqva, Israel. Patients: Thirteen gifts with idiopathic central precocious puberty. Results: Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 ± 5.6 to 21.5 ± 12.5 μg/L (mean ± SD). Conclusions: The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.

Original language	English
Pages (from-to)	285-287
Number of pages	3
Journal	Fertility and Sterility
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/s0015-0282(16)57724-3
State	Published - 1995
Externally published	Yes

Keywords

GnRH-a treatment
Prolactin
precocious puberty

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10.1016/s0015-0282(16)57724-3

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title = "Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue decapeptyl in girls with central precocious puberty",

abstract = "Objective: To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Design: Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months. Setting: Pediatric Endocrine Clinic, Hasbaron Hospital, Petah Tiqva, Israel. Patients: Thirteen gifts with idiopathic central precocious puberty. Results: Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 ± 5.6 to 21.5 ± 12.5 μg/L (mean ± SD). Conclusions: The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.",

keywords = "GnRH-a treatment, Prolactin, precocious puberty",

author = "A. Kauschansky and M. Nussinovitch and M. Frydman and A. Yeshaya and Z. Ben-Rafael",

year = "1995",

doi = "10.1016/s0015-0282(16)57724-3",

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AU - Kauschansky, A.

AU - Nussinovitch, M.

AU - Frydman, M.

AU - Yeshaya, A.

AU - Ben-Rafael, Z.

PY - 1995

Y1 - 1995

N2 - Objective: To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Design: Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months. Setting: Pediatric Endocrine Clinic, Hasbaron Hospital, Petah Tiqva, Israel. Patients: Thirteen gifts with idiopathic central precocious puberty. Results: Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 ± 5.6 to 21.5 ± 12.5 μg/L (mean ± SD). Conclusions: The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.

AB - Objective: To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Design: Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months. Setting: Pediatric Endocrine Clinic, Hasbaron Hospital, Petah Tiqva, Israel. Patients: Thirteen gifts with idiopathic central precocious puberty. Results: Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 ± 5.6 to 21.5 ± 12.5 μg/L (mean ± SD). Conclusions: The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.

KW - GnRH-a treatment

KW - Prolactin

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Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue decapeptyl in girls with central precocious puberty

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Keywords

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