Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Riccardo Balzan, Mor Mishkovsky*, Yana Simonenko, Ruud B. van Heeswijk, Rolf Gruetter, Uzi Eliav, Gil Navon, Arnaud Comment

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6Li. The 6Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalContrast Media and Molecular Imaging
Volume11
Issue number1
DOIs
StatePublished - 1 Jan 2016

Funding

FundersFunder number
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung157547

    Keywords

    • Blood
    • Deoxyhemoglobin
    • Dynamic nuclear polarization
    • Hyperpolarization
    • Lithium
    • MRI
    • Magnetic resonance
    • Molecular imaging

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