@article{4c9877b546dc418697214d5a64ce8532,
title = "Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents",
abstract = "Lithium is widely used in psychotherapy. The 6Li isotope has a long intrinsic longitudinal relaxation time T1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as 6Li may provide a novel avenue for molecular imaging.",
keywords = "DNP, Hyperpolarization, Lithium-6, Relaxivity",
author = "{Van Heeswijk}, {Ruud B.} and Kai Uffmann and Arnaud Comment and Fiodar Kurdzesau and Chiara Perazzolo and Cristina Cudalbu and Sami Jannin and Konter, {Jacobus A.} and Patrick Hautle and {Van Den Brandt}, Ben and Gil Navon and {Van Der Klink}, {Jacques J.} and Rolf Gruetter",
year = "2009",
month = jun,
doi = "10.1002/mrm.21952",
language = "אנגלית",
volume = "61",
pages = "1489--1493",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "6",
}