Hyperoxaluria in women with vulvar vestibulitis syndrome

Alexander Greenstein*, Idan Militscher, Juza Chen, Haim Matzkin, Joseph B. Lessing, Liora Abramov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To determine whether evaluation and treatment of hyperoxaluria in vulvar vestibulitis syndrome (VVS) is justified. STUDY DESIGN: Forty women (mean age, 24.5 years; range, 18-35) diagnosed with VVS at a sex therapy clinic participated. Diagnosis of VVS relied upon Friedrich's criteria: (1) severe vulvar vestibular pain upon touch or attempted vaginal entry, (2) tenderness to pressure localized within the vulvar vestibule, and (3) physical findings confined to vulvar erythema of various degrees. Oxalate was measured in 24-hour urine samples. Women with hyperoxaluria (urine oxalate >50 mg/24 h) were placed on a low-oxalate diet and oral calcium citrate as single therapy and reevaluated 3 months later. RESULTS: Hyperoxaluria was diagnosed in 7 women (17.5%), of whom 1 demonstrated an objective improvement and could have pain-free vaginal intercourse following treatment, yielding a 2.5% benefit from the evaluation and treatment of hyperoxaluria. CONCLUSION: There is no justification for evaluation and treatment of hyperoxaluria in women with VVS due to its low yield and economic burden.

Original languageEnglish
Pages (from-to)500-502
Number of pages3
JournalThe Journal of reproductive medicine
Issue number6
StatePublished - Jun 2006


  • Hyperoxaluria
  • Vulvar diseases
  • Vulvar vestibulitis syndrome


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