Hypermetabolic Axillary Lymphadenopathy After Shingrix Vaccination for Varicella Zoster Virus

Yael Eshet*, Michal Eifer, Liran Domachevsky, Noam Tau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 67-year-old woman underwent staging 18F-FDG PET/CT scan for recently diagnosed breast cancer. Her scan showed a highly hypermetabolic right breast mass, with ipsilateral hypermetabolic axillary lymph nodes. The contralateral axillary lymph nodes were also enlarged with avid FDG uptake, alongside focal increased uptake in the left deltoid muscle. Upon investigation, the patient reported receiving the new zoster recombinant adjuvanted varicella zoster vaccine (Shingrix, GlaxoSmithKline) 4 days before the scan. The lymph node uptake could be potential pitfall for cancer staging.

Original languageEnglish
Pages (from-to)E127-E128
JournalClinical Nuclear Medicine
Issue number3
StatePublished - 1 Mar 2024


  • Shingrix
  • breast cancer
  • vaccination
  • varicella zoster

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