Hyperlactatemia in children following brain tumor resection: prevalence, associated factors, and clinical significance

Miri Gelbart, Elhanan Nahum, Maoz Gelbart, Eytan Kaplan, Gili Kadmon, Amir Kershenovich, Helen Toledano, Avichai Weissbach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: Hyperlactatemia is associated with worse outcome among critically ill patients. The prevalence of hyperlactatemia in children following craniotomy for intracranial tumor resection is unknown. This study was designed to assess the prevalence, associated factors, and significance of postoperative hyperlactatemia in this context. Methods: A retrospective study was conducted at an intensive care unit of a tertiary, pediatric medical center. Children younger than 18 years admitted following craniotomy for brain tumor resection between October 2004 and November 2019 were included. Results: Overall, 222 elective craniotomies performed in 178 patients were analyzed. The mean age ± SD was 8.5 ± 5.5 years. All but two patients survived to discharge. All were hemodynamically stable. Early hyperlactatemia, defined as at least one blood lactate level ≥ 2.0 mmol/L during the first 24 h into admission, presented following 74% of the craniotomies; lactate normalized within a mean ± SD of 11 ± 6.1 h. The fluid balance per body weight at 12 h and 24 h into the intensive care unit admission was similar in children with and without hyperlactatemia [7.0 ± 17.6 vs 3.5 ± 16.4 ml/kg, p = 0.23 and 4.0 ± 27.2 vs 4.6 ± 29.4 ml/kg, p = 0.96; respectively]. Hyperlactatemia was associated with higher maximal blood glucose, older age, and a pathological diagnosis of glioma. Intensive care unit length of stay was similar following craniotomies with and without hyperlactatemia (p = 0.57). Conclusions: Hyperlactatemia was common in children following craniotomy for brain tumor resection. It was not associated with hemodynamic impairment or with a longer length of stay.

Original languageEnglish
Pages (from-to)739-745
Number of pages7
JournalChild's Nervous System
Issue number4
StatePublished - Apr 2022


  • Craniotomy
  • Hyperlactatemia
  • Neurocritical care
  • Pediatric intensive care
  • Pediatric neurosurgery


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