Hyperhomocystinemia in pseudoexfoliation glaucoma

Igal Leibovitch*, Shimon Kurtz, Gabi Shemesh, Michaella Goldstein, Ben ami Sela, Moshe Lazar, Anat Loewenstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To determine the prevalence of hyperhomocystinemia in patients with pseudoexfoliation glaucoma. Patients and Methods: This prospective study included 30 patients with glaucoma and 30 age-matched controls with no history of ocular disease who were undergoing routine physical checkups. Plasma homocysteine levels of all the study participants were determined using high-performance liquid chromatography, and values exceeding 15 μmol/L were considered elevated. Results: The mean plasma homocysteine level was 16.80 ± 3.20 and 12.39 ± 1.97 μmol/L in glaucoma patients and controls, respectively (P<0.0001). Fifteen glaucoma patients (50%) had hyperhomocystinemia compared with 3 controls (10%) (P = 0.0015). Conclusion: Hyperhomocystinemia may be associated with pseudoexfoliation glaucoma, which may partially explain the increased risk of vascular diseases among patients with pseudoexfoliation syndrome.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalJournal of Glaucoma
Issue number1
StatePublished - Feb 2003


  • Glaucoma
  • Homocysteine
  • Hyperhomocystinemia
  • Pseudoexfoliation


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