TY - JOUR
T1 - Hyperhomocysteinemia is common in patients with antiphospholipid syndrome and may contribute to expression of major thrombotic events
AU - Avivi, I.
AU - Lanir, N.
AU - Hoffman, R.
AU - Brenner, Benjamin
PY - 2002/3
Y1 - 2002/3
N2 - Homocysteine plasma levels were measured by high-performance liquid chromatography in 52 patients with primary anti-phospholipid syndrome (APS). Elevated homocysteine concentrations (≥ 15 μmol/l) were found in 16/52 (30.8%) APS patients. Elevated homocysteine levels were found to be associated with an increased risk for a major thromboembolic event (50 versus 16.7%, P = 0.014). Hyperhomocysteinemia is a common finding in APS patients, and may contribute to severity of thrombotic tendency observed in this syndrome.
AB - Homocysteine plasma levels were measured by high-performance liquid chromatography in 52 patients with primary anti-phospholipid syndrome (APS). Elevated homocysteine concentrations (≥ 15 μmol/l) were found in 16/52 (30.8%) APS patients. Elevated homocysteine levels were found to be associated with an increased risk for a major thromboembolic event (50 versus 16.7%, P = 0.014). Hyperhomocysteinemia is a common finding in APS patients, and may contribute to severity of thrombotic tendency observed in this syndrome.
KW - Antiphospholipid syndrome
KW - Hyperhomocysteinemia
KW - Thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=0036489808&partnerID=8YFLogxK
U2 - 10.1097/00001721-200203000-00013
DO - 10.1097/00001721-200203000-00013
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C2 - 11914660
AN - SCOPUS:0036489808
SN - 0957-5235
VL - 13
SP - 169
EP - 172
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 2
ER -