TY - JOUR
T1 - Hypergonadotropic hypogonadism after ovarian tissue cryopreservation on a 13-year-old female
T2 - A case report and review of the literature
AU - Moussaoui, Dehlia
AU - Bénard, Julie
AU - Yaron, Michal
AU - Bernard, Fanette
AU - Adam, Cécile
AU - Vulliemoz, Nicolas
AU - Bouthors, Thérèse
AU - Andrey, Véronique
AU - Ansari, Marc
AU - Girardin, Céline
AU - Gumy-Pause, Fabienne
N1 - Publisher Copyright:
© 2020 Elsevier Masson SAS
PY - 2021/2
Y1 - 2021/2
N2 - Ovarian failure is a major long-term adverse event following gonadotoxic treatment of malignant diseases. Ovarian tissue cryopreservation can be offered in some conditions to preserve fertility. We report the case of a 13-year-old female with a diagnosis of acute myeloid leukemia, who presented with hypergonadotropic hypogonadism after unilateral ovariectomy for fertility preservation and before highly gonadotoxic treatment. Even though damage seemed only partial, this case suggests that the remaining contralateral ovarian function may be compromised after ovarian tissue cryopreservation, leading per se to a hypergonadotropic hypogonadism. Although indication of ovarian cryopreservation is not called into question in situations of highly gonadotoxic therapy, this procedure should only be performed after evaluation by a specialized multidisciplinary team and provided a solid indication.
AB - Ovarian failure is a major long-term adverse event following gonadotoxic treatment of malignant diseases. Ovarian tissue cryopreservation can be offered in some conditions to preserve fertility. We report the case of a 13-year-old female with a diagnosis of acute myeloid leukemia, who presented with hypergonadotropic hypogonadism after unilateral ovariectomy for fertility preservation and before highly gonadotoxic treatment. Even though damage seemed only partial, this case suggests that the remaining contralateral ovarian function may be compromised after ovarian tissue cryopreservation, leading per se to a hypergonadotropic hypogonadism. Although indication of ovarian cryopreservation is not called into question in situations of highly gonadotoxic therapy, this procedure should only be performed after evaluation by a specialized multidisciplinary team and provided a solid indication.
KW - Fertility preservation
KW - Gonadotoxic treatment
KW - Hypergonadotropic hypogonadism
KW - Oncofertility
KW - Ovarian failure
KW - Ovarian tissue cryopreservation
UR - http://www.scopus.com/inward/record.url?scp=85098524056&partnerID=8YFLogxK
U2 - 10.1016/j.jogoh.2020.102029
DO - 10.1016/j.jogoh.2020.102029
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C2 - 33259962
AN - SCOPUS:85098524056
SN - 0368-2315
VL - 50
JO - Journal of Gynecology Obstetrics and Human Reproduction
JF - Journal of Gynecology Obstetrics and Human Reproduction
IS - 2
M1 - 102029
ER -
