Abstract
Hyperglucagonemia accompanies several clinical conditions characterized by increased amylase/creatinine clearance. We tested the hypothesis that glucagon may be responsible for this augmented clearance. Therefore, a constant glucagon infusion was given to eight volunteers in order to attain physiological levels comparable to those obtained during acute pancreatitis. The amylase/creatinine clearance increased from 0.84 ± 0.8% to a mean of 1.30 ± 1.14% (p < 0.001). This was, however, less than the clearance of 2.94 ± 0.23% observed during acute pancreatitis. The rise in amylase clearance during acute pancreatitis is, therefore, only partially explained by the hyperglucagonemia.
| Original language | English |
|---|---|
| Pages (from-to) | 99-101 |
| Number of pages | 3 |
| Journal | American Journal of Gastroenterology |
| Volume | 78 |
| Issue number | 2 |
| State | Published - 1983 |
| Externally published | Yes |