Hypercapnia in relation to pulmonary function in duchenne muscular dystrophy

Gerard J. Canny; Amir Szeinberg; Henry Levison; Jan Koreska

doi:10.1002/ppul.1950060308

Hypercapnia in relation to pulmonary function in duchenne muscular dystrophy

Gerard J. Canny
, Amir Szeinberg
, Henry Levison^*
, Jan Koreska

^*Corresponding author for this work

University of Toronto

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Pa_co2 values in the low or normal range. Only six older patients had hypercapnia (Pa_co2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.

Original language	English
Pages (from-to)	169-171
Number of pages	3
Journal	Pediatric Pulmonology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/ppul.1950060308
State	Published - 1989
Externally published	Yes

Keywords

Pa vs. FVC, correlation of
arterialized capillary blood
forced vital capacity
hypercapnic respiratory failure
preterminal event

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10.1002/ppul.1950060308

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abstract = "Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Paco2 values in the low or normal range. Only six older patients had hypercapnia (Paco2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40\% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.",

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AU - Koreska, Jan

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Y1 - 1989

N2 - Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Paco2 values in the low or normal range. Only six older patients had hypercapnia (Paco2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.

AB - Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Paco2 values in the low or normal range. Only six older patients had hypercapnia (Paco2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.

KW - Pa vs. FVC, correlation of

KW - arterialized capillary blood

KW - forced vital capacity

KW - hypercapnic respiratory failure

KW - preterminal event

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ER -

Hypercapnia in relation to pulmonary function in duchenne muscular dystrophy

Abstract

Keywords

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