TY - JOUR
T1 - Hypercapnia in relation to pulmonary function in duchenne muscular dystrophy
AU - Canny, Gerard J.
AU - Szeinberg, Amir
AU - Levison, Henry
AU - Koreska, Jan
PY - 1989
Y1 - 1989
N2 - Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Paco2 values in the low or normal range. Only six older patients had hypercapnia (Paco2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.
AB - Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Paco2 values in the low or normal range. Only six older patients had hypercapnia (Paco2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.
KW - Pa vs. FVC, correlation of
KW - arterialized capillary blood
KW - forced vital capacity
KW - hypercapnic respiratory failure
KW - preterminal event
UR - http://www.scopus.com/inward/record.url?scp=0024487890&partnerID=8YFLogxK
U2 - 10.1002/ppul.1950060308
DO - 10.1002/ppul.1950060308
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AN - SCOPUS:0024487890
SN - 8755-6863
VL - 6
SP - 169
EP - 171
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 3
ER -