Hypercalcemia in carcinoma of the breast without evidence of bone destruction: Beneficial effect of hormonal therapy

Mario Sztern, Ariel Barkan, Raphael Marilus, Ilana Blum*, Erika Rakowsky, Ruth Shainkin‐Kestenbaum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A premenopausal woman with soft tissue metastases from a carcinoma of the breast developed hypercalcemia with hypophosphatemia, reduced tubular reabsorption of phosphate, elevated urinary cyclic AMP levels and normal serum PTH levels. During the course of the disease, metastatic pleural effusion which contained high PTH levels was observed. Hormonal therapy with testosterone followed by tamoxifen induced normalization of her serum calcium concomitant with the disappearance of the pleural effusion and reduction in the size of her lung metastases. The correlation between the efficacy of antitumor treatment on pleural effusion, lung metastases, and normalization of serum calcium, as well as the elevated PTH level in the pleural effusion, suggest that this breast carcinoma secreted a PTH‐like substance.

Original languageEnglish
Pages (from-to)2383-2385
Number of pages3
JournalCancer
Volume48
Issue number11
DOIs
StatePublished - 1 Dec 1981

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