TY - JOUR
T1 - Hyperbaric oxygen therapy in acute stroke
T2 - is it time for Justitia to open her eyes?
AU - Mijajlovic, Milija D.
AU - Aleksic, Vuk
AU - Milosevic, Nenad
AU - Bornstein, Natan M.
N1 - Publisher Copyright:
© 2020, Fondazione Società Italiana di Neurologia.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Hypoxia is a critical component of neuronal death in patients with stroke. Therefore increasing oxygenation of brain tissue seems to be a logical therapy against cerebral ischemia. Oxygen therapy exists in two modalities: normobaric hyperoxia therapy and hyperbaric oxygen therapy (HBO). HBO is a therapeutic procedure in which pure (100%) oxygen is administered at greater than atmospheric pressure in HBO therapy chambers. In this review article, we aimed to summarize the current knowledge regarding the therapeutic use of HBO in acute stroke patients. Literature review and electronic search were performed using PubMed, Medscape, and UpToDate with the keywords stroke, acute stroke, hyperbaric oxygen therapy, and hyperoxia. According to the reviewed literature, the use of HBO as routine stroke therapy cannot be justified in acute stage of stroke. More randomized, controlled studies are needed regarding safety and especially effectives of HBO in stroke patients. Also, standardized definition of HBO should be proposed and used in all future studies.
AB - Hypoxia is a critical component of neuronal death in patients with stroke. Therefore increasing oxygenation of brain tissue seems to be a logical therapy against cerebral ischemia. Oxygen therapy exists in two modalities: normobaric hyperoxia therapy and hyperbaric oxygen therapy (HBO). HBO is a therapeutic procedure in which pure (100%) oxygen is administered at greater than atmospheric pressure in HBO therapy chambers. In this review article, we aimed to summarize the current knowledge regarding the therapeutic use of HBO in acute stroke patients. Literature review and electronic search were performed using PubMed, Medscape, and UpToDate with the keywords stroke, acute stroke, hyperbaric oxygen therapy, and hyperoxia. According to the reviewed literature, the use of HBO as routine stroke therapy cannot be justified in acute stage of stroke. More randomized, controlled studies are needed regarding safety and especially effectives of HBO in stroke patients. Also, standardized definition of HBO should be proposed and used in all future studies.
KW - Hyperbaric oxygen therapy
KW - Hyperoxia
KW - Normobaric hyperoxia therapy
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85077723484&partnerID=8YFLogxK
U2 - 10.1007/s10072-020-04241-8
DO - 10.1007/s10072-020-04241-8
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C2 - 31925614
AN - SCOPUS:85077723484
SN - 1590-1874
VL - 41
SP - 1381
EP - 1390
JO - Neurological Sciences
JF - Neurological Sciences
IS - 6
ER -