Hyperbaric oxygen therapy for chemoradiation myelitis

Aliza Zeidman*, Zinaida Fradin, Eyal Fenig

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Radiation induced myelitis is a rare complication following high dose radiotherapy. Intrathecal chemotherapy accelerates its CNS effects. We report a young woman with aggressive lymphoma presented as superior vena cava syndrome. The patient was treated with radiotherapy and intrathecal chemotherapy, achieved complete remission and 17 month later developed chronic progressive radiation myelitis (CPRM). The difficulties of diagnosis and management of CPRM are discussed. In the absence of clear guidelines, and since there is no clear effective treatment, we decided to treat the patient with hyper baric oxygen with slight improvement and stabilization in her neurological condition. Clearly, more experience and well controlled trials to establish guidelines are needed.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
Issue number2
StatePublished - Apr 2004


  • Chronic progressive radiation myelitis (CPRM)
  • Hyperbaric oxygen
  • Methotrexate neurotoxicity


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