Hydrops fetalis associated with homozygosity for hemoglobin Taybe (α 38/39 THR deletion) in newborn triplets

Shmuel Arnon, Hannah Tamary, Orly Dgany, Ita Litmanovitz, Rivka Regev, Sofia Bauer, Tzipora Dolfin, Joanne Yacobovich, Baruch Wolach, Lutfi Jaber

Research output: Contribution to journalArticlepeer-review

Abstract

Hemoglobin Taybe is an unstable α-chain hemoglobin variant caused by a deletion of a threonine residue at codon 38 or 39 of the α-1 globin chain. We describe preterm infant triplets born with hydrops fetalis and anemia who were found by DNA analysis to be homozygous for hemoglobin Taybe. All three infants developed intrauterine hemolytic anemia, which subsequently led to hydrops fetalis. To the best of our knowledge, this is the first description of hydrops fetalis associated with this hemoglobinopathy. We suggest that hemoglobin Taybe be considered in the differential diagnosis of hydrops fetalis and that known affected fetuses be carefully followed both antenatally and postnatally.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalAmerican Journal of Hematology
Volume76
Issue number3
DOIs
StatePublished - Jul 2004

Keywords

  • Alpha thalassemia
  • Hemoglobin Taybe
  • Hydrops fetalis

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