Hydrophilic acrylic intraocular lens as a drug-delivery system for fourth-generation fluoroquinolones

Guy Kleinmann*, David J. Apple, Jesse Chew, Brian Hunter, Scott Stevens, Scott Larson, Nick Mamalis, Randall J. Olson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Purpose: To evaluate the ability and safety of a hydrophilic acrylic intraocular lens (IOL) as a drug-delivery system for commercially available gatifloxacin and moxifloxacin. Setting: David J. Apple, MD, Laboratories for Ophthalmic Research, John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, USA. Methods: Thirty rabbits were divided into 2 similar groups. In Group A (15 rabbits, 30 eyes), hydrophilic acrylic IOLs (C-flex, Rayner Intraocular Lenses, Ltd.) presoaked for 24 hours in commercially available solutions of gatifloxacin 3 mg/mL or moxifloxacin 5 mg/mL were implanted after evacuation of the crystalline lens. Group B (15 rabbits, 30 eyes) had topical preoperative and postoperative cataract prophylaxis with gatifloxacin 3 mg/mL or moxifloxacin 5 mg/mL; IOLs that were not presoaked were also implanted after evacuation of the crystalline lenses. In both groups, aqueous humor samples were taken 4, 8, or 12 hours after IOL implantation (5 eyes at each time point) to determine the antibiotic concentrations. Clinical examinations were performed 24 hours postoperatively. Results: The antibiotic concentrations in Group A (presoaked IOLs) were statistically significantly higher than those in Group B (topical) for both antibiotics in all postoperative samples except moxifloxacin at 12 hours. In both groups, there was no statistically significant difference between the concentrations of the 2 antibiotics. No eye showed signs of clinical toxicity. Conclusion: Results show the C-flex IOL is a safe and effective drug-delivery system for fourth-generation fluoroquinolones.

Original languageEnglish
Pages (from-to)1717-1721
Number of pages5
JournalJournal of Cataract and Refractive Surgery
Volume32
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

Funding

FundersFunder number
ASCRS Foundation
Rayner Intraocular Lenses, Ltd.

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