TY - JOUR
T1 - Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion
AU - Golik, Ahuva
AU - Modai, David
AU - Weissgarten, Joshua
AU - Cohen, Natan
AU - Averbukh, Zhan
AU - Sigler, Erika
AU - Zaidenstein, Ronit
AU - Shaked, Uri
PY - 1987/7
Y1 - 1987/7
N2 - Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc-sparing effect.
AB - Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc-sparing effect.
UR - http://www.scopus.com/inward/record.url?scp=0023179216&partnerID=8YFLogxK
U2 - 10.1038/clpt.1987.105
DO - 10.1038/clpt.1987.105
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AN - SCOPUS:0023179216
SN - 0009-9236
VL - 42
SP - 42
EP - 44
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 1
ER -