Hydantoin immunosuppression and carcinogenesis

Y. Levo, O. Markowitz, N. Trainin

Research output: Contribution to journalArticlepeer-review


The immunological response of mice submitted to hydantoin treatment was determined. Hydantoin reduced the absolute number of spleen cells in treated animals and did not modify spleen cells reactivity to concanavalin A, although the response to SRBC challenge, as measured by the Jerne plaque forming cell technique, was significantly decreased. Following these findings, the influence of hydantoin on carcinogenesis was evaluated by using the model of urethane induced lung adenomas in SWR mice. Treatment with hydantoin significantly reduced the incidence of the induced adenomas. The authors confirmed that hydantoin modifies the immune response of the host mainly by depressing its humoral function and showed that this effect was associated with an inhibitory effect on tumour induction.

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1975
Externally publishedYes


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