Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon

M. Yaron, I. Yaron, O. Smetana, E. Eylan, M. Herzberg

Research output: Contribution to journalArticlepeer-review

Abstract

Poly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts. Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin. Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter. Cells grown with Poly I:C were virus resistant and interferon was detected in their medium. Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells. A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.

Original languageEnglish
Pages (from-to)1315-1320
Number of pages6
JournalArthritis and Rheumatology
Volume19
Issue number6
DOIs
StatePublished - 1976

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