TY - JOUR
T1 - Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon
AU - Yaron, M.
AU - Yaron, I.
AU - Smetana, O.
AU - Eylan, E.
AU - Herzberg, M.
PY - 1976
Y1 - 1976
N2 - Poly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts. Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin. Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter. Cells grown with Poly I:C were virus resistant and interferon was detected in their medium. Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells. A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.
AB - Poly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts. Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin. Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter. Cells grown with Poly I:C were virus resistant and interferon was detected in their medium. Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells. A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0017017987&partnerID=8YFLogxK
U2 - 10.1002/art.1780190612
DO - 10.1002/art.1780190612
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AN - SCOPUS:0017017987
SN - 2326-5191
VL - 19
SP - 1315
EP - 1320
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
IS - 6
ER -