Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients

Yael Einbinder; Jeffrey Perl; Naomi Nacasch; Alon Bnaya; Linda Shavit; Daniel Erez; Moshe Shashar; Tamar Halperin; Ayelet Grupper; Sydney Benchetrit; Ori Wand; Keren Cohen-Hagai

doi:10.1159/000525309

Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients

Yael Einbinder, Jeffrey Perl, Naomi Nacasch, Alon Bnaya, Linda Shavit, Daniel Erez, Moshe Shashar, Tamar Halperin, Ayelet Grupper, Sydney Benchetrit, Ori Wand, Keren Cohen-Hagai^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.

Original language	English
Pages (from-to)	586-590
Number of pages	5
Journal	American Journal of Nephrology
Volume	53
Issue number	7
DOIs	https://doi.org/10.1159/000525309
State	Published - 18 Aug 2022

Keywords

COVID-19
Hemodialysis
Humoral response
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000525309

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Einbinder, Y., Perl, J., Nacasch, N., Bnaya, A., Shavit, L., Erez, D., Shashar, M., Halperin, T., Grupper, A., Benchetrit, S., Wand, O., & Cohen-Hagai, K. (2022). Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients. American Journal of Nephrology, 53(7), 586-590. https://doi.org/10.1159/000525309

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abstract = "The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.",

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Einbinder, Y, Perl, J, Nacasch, N, Bnaya, A, Shavit, L, Erez, D, Shashar, M, Halperin, T, Grupper, A , Benchetrit, S, Wand, O & Cohen-Hagai, K 2022, 'Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients', American Journal of Nephrology, vol. 53, no. 7, pp. 586-590. https://doi.org/10.1159/000525309

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AU - Shavit, Linda

AU - Erez, Daniel

AU - Shashar, Moshe

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AU - Wand, Ori

AU - Cohen-Hagai, Keren

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Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients

Abstract

Keywords

UN SDGs

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