Human protein interaction networks across tissues and diseases

Esti Yeger-Lotem, Roded Sharan

Research output: Contribution to journalShort surveypeer-review


Protein interaction networks are an important framework for studying protein function, cellular processes, and genotype-to-phenotype relationships. While our view of the human interaction network is constantly expanding, less is known about networks that form in biologically important contexts such as within distinct tissues or in disease conditions. Here we review efforts to characterize these networks and to harness them to gain insights into the molecular mechanisms underlying human disease.

Original languageEnglish
Article number257
JournalFrontiers in Genetics
Issue numberAug
StatePublished - 2015


  • Disease-specific network
  • Gene expression
  • Network perturbation
  • Protein interaction network
  • Tissue-specific network


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