Human peritoneal macrophage activity is increased by tuftsin

Ze'ev Kain, Michael Alkan, Cidio Chaimovitz, Shraga Segal, Matti Fridkin, Rachel Levy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Peritonitis caused by Candida albicans is a major complication of continuous ambulatory peritoneal dialysis (CAPD). Increasing the activity of the peritoneal macrophages- the predominant cell type found in the peritoneal cavity-may be of great importance in the prevention and therapy of peritonitis. Therefore, the activating effect of tuftsin was studied on human peritoneal macrophages from CAPD patients. Tuftsin induced a biphasic effect on macrophage activity within a range of 2×10-9-2×10-6M, with a maximal activity 2×10-7M. At this concentration,tuftsin enhanced by twofold cell association with radiolabelled candida (from 2±0.2 to 4±0.2 candida per macrophage) and superoxide anion production in response to exposure to candida (from 150±20 to 300±20 nmoles/mg). These results suggest the potential use of tuftsin as a therapeutic drug.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalImmunology Letters
Issue number3
StatePublished - 1 Jun 1989
Externally publishedYes


  • Candida association
  • Peritoneal macrophages
  • Tuftsin
  • superoxide production


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