Human monoclonal anti‐DNA antibodies react as lymphocytotoxic antibodies

Yehuda Shoenfeld*, Rina Zamir, Henri Joshua, Gad Lavie, Jacob Pinkhas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Two out of 25 monoclonal anti‐DNA autoantibodies that were produced by human‐human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4°C) as well as at warm (37°C) temperatures. The lymphocytotoxic activity of the monoclonal anti‐DNA antibodies could be inhibited by prior incubation of the antibodies with either polynucleotides, e.g. poly (I), poly(dT) or anti‐idiotypic antibodies, that had been raised against a dominant anti‐DNA antibody. The cross‐reactivity between nuclear material and lymphocyte membrane raises the question whether these apparently diverse materials have a shared epitope. The cross‐reactivity between anti‐DNA antibodies and lymphocyte membrane may account in part for the lymphopenia observed in systemic lupus erythematosus patients.

Original languageEnglish
Pages (from-to)1024-1028
Number of pages5
JournalEuropean Journal of Immunology
Volume15
Issue number10
DOIs
StatePublished - 1985

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