Induction of ovulation with sequential application of human gonadotropins-follicle stimulating hormone (FSH) and luteinizing hormone (LH)-is today an established procedure. FSH, formerly obtained from animal sources and now extracted from urine of postmenopausal women (Pergonal), is available commercially and easy to administer. During the last 7 years, 110 patients suffering from various types of anovulation have been treated with 202 courses of Pergonal combined with human chorionic gonadotropins (HCG). The dosage of Pergonal was adjusted to the individual reaction of the patient, as evaluated by urinary estrogen excretion, the cervical mucus arborization test, and vaginal cytology. This treatment resulted in 61 pregnancies. There have been 34 deliveries, 11 patients are still pregnant, and there have been 16 abortions. Adverse reaction resulting from ovarian hyperstimulation were encountered. There is no relationship between the dosage of Pergonal administered and the severity or number of reactions. The combined administration of Pergonal with HCG can be regarded as a significant step forward in the treatment of anovulation.