Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens

Israel Yust; John Wunderlich; Dean L. Mann; G. N. Rogentine; Brigid Leventhal; Ronald Yankee; Robert Graw

doi:10.1038/249263a0

Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens

Israel Yust^*, John Wunderlich, Dean L. Mann, G. N. Rogentine, Brigid Leventhal, Ronald Yankee, Robert Graw

^*Corresponding author for this work

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

EXPRESSION of the major transplantation antigens in humans is generally considered to be controlled by the genes of the HL-A region^1-4. Skin, kidney and bone marrow transplants usually survive longer when donors and recipients are HL-A identical than when they are not^5-7. However, the fact that grafts are still rejected with HL-A identity and negative mixed lymphocyte reactivity (MLR)^8-11 strongly suggests the presence of minor transplantation antigens. The major problem to date has been the development of in vitro assay systems to detect these antigens.

Original language	English
Pages (from-to)	263-265
Number of pages	3
Journal	Nature
Volume	249
Issue number	5454
DOIs	https://doi.org/10.1038/249263a0
State	Published - 1974
Externally published	Yes

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abstract = "EXPRESSION of the major transplantation antigens in humans is generally considered to be controlled by the genes of the HL-A region1-4. Skin, kidney and bone marrow transplants usually survive longer when donors and recipients are HL-A identical than when they are not5-7. However, the fact that grafts are still rejected with HL-A identity and negative mixed lymphocyte reactivity (MLR)8-11 strongly suggests the presence of minor transplantation antigens. The major problem to date has been the development of in vitro assay systems to detect these antigens.",

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AU - Yust, Israel

AU - Wunderlich, John

AU - Mann, Dean L.

AU - Rogentine, G. N.

AU - Leventhal, Brigid

AU - Yankee, Ronald

AU - Graw, Robert

PY - 1974

Y1 - 1974

N2 - EXPRESSION of the major transplantation antigens in humans is generally considered to be controlled by the genes of the HL-A region1-4. Skin, kidney and bone marrow transplants usually survive longer when donors and recipients are HL-A identical than when they are not5-7. However, the fact that grafts are still rejected with HL-A identity and negative mixed lymphocyte reactivity (MLR)8-11 strongly suggests the presence of minor transplantation antigens. The major problem to date has been the development of in vitro assay systems to detect these antigens.

AB - EXPRESSION of the major transplantation antigens in humans is generally considered to be controlled by the genes of the HL-A region1-4. Skin, kidney and bone marrow transplants usually survive longer when donors and recipients are HL-A identical than when they are not5-7. However, the fact that grafts are still rejected with HL-A identity and negative mixed lymphocyte reactivity (MLR)8-11 strongly suggests the presence of minor transplantation antigens. The major problem to date has been the development of in vitro assay systems to detect these antigens.

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Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens

Abstract

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