TY - JOUR
T1 - Human intracranial recordings and cognitive neuroscience
AU - Mukamel, Roy
AU - Fried, Itzhak
PY - 2012
Y1 - 2012
N2 - The ultimate goal of neuroscience research is to understand the operating mechanism of the human brain and to exploit this understanding to devise methods for repair when it malfunctions. A key feature of this operating mechanism is electrical activity of single brain cells and cell assemblies. For obvious ethical reasons, scientists rely mostly on animal research in the study of such signals. Research in humans is often limited to electrical signals that can be recorded at the scalp or to surrogates of electrical activity, namely magnetic source imaging and measures of regional blood flow and metabolism. Invasive brain recordings performed in patients during various clinical procedures provide a unique opportunity to record high-resolution signals in vivo from the human braindata that are otherwise unavailable. Of special value are the rare opportunities to record in awake humans the activity of single brain cells and small cellular assemblies. These recordings provide a unique view on aspects of human cognition that are impossible to study in animals, including language, imagery, episodic memory, volition, and even consciousness. In the current review we discuss the unique contribution of invasive recordings from patients to the field of cognitive neuroscience.
AB - The ultimate goal of neuroscience research is to understand the operating mechanism of the human brain and to exploit this understanding to devise methods for repair when it malfunctions. A key feature of this operating mechanism is electrical activity of single brain cells and cell assemblies. For obvious ethical reasons, scientists rely mostly on animal research in the study of such signals. Research in humans is often limited to electrical signals that can be recorded at the scalp or to surrogates of electrical activity, namely magnetic source imaging and measures of regional blood flow and metabolism. Invasive brain recordings performed in patients during various clinical procedures provide a unique opportunity to record high-resolution signals in vivo from the human braindata that are otherwise unavailable. Of special value are the rare opportunities to record in awake humans the activity of single brain cells and small cellular assemblies. These recordings provide a unique view on aspects of human cognition that are impossible to study in animals, including language, imagery, episodic memory, volition, and even consciousness. In the current review we discuss the unique contribution of invasive recordings from patients to the field of cognitive neuroscience.
KW - Brain-machine interface
KW - Deep brain stimulation
KW - Depth electrodes
KW - Electrocorticography (ECoG)
KW - Extra-cellular unit recording
KW - Local field potentials
UR - http://www.scopus.com/inward/record.url?scp=82955169695&partnerID=8YFLogxK
U2 - 10.1146/annurev-psych-120709-145401
DO - 10.1146/annurev-psych-120709-145401
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AN - SCOPUS:82955169695
SN - 0066-4308
VL - 63
SP - 511
EP - 537
JO - Annual Review of Psychology
JF - Annual Review of Psychology
ER -