Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides

Iris Amitay-Laish, Ronit Sarid, Dan Ben-Amitai, Inna Kalt, Shiri Rivka Masa, Michael David, Meora Feinmesser, Emmilia Hodak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Human herpesvirus (HHV) 8, an essential etiologic agent of Kaposi sarcoma, is also associated with several lymphoproliferative disorders. The involvement of HHV 8 in mycosis fungoides (MF) and large plaque parapsoriasis (LPP) is controversial, with contradictory reports from various countries worldwide. Objective: We sought to investigate the presence of the HHV 8 genome in skin lesions of LPP and early-stage sporadic, familial, and juvenile MF in patients in Israel. Methods: Archival paraffin-embedded and frozen samples from skin biopsies of untreated patients with LPP and early-stage MF performed in 1990 through 2006 were randomly collected from the department of dermatology of a tertiary medical center in central Israel. DNA was extracted, and a TaqMan-based real-time polymerase chain reaction assay specific for the K6 gene region was used to detect the HHV 8 genome. Results: A total of 46 biopsies were sampled from 11 patients with LPP and 35 with early-stage MF (17 adults with sporadic MF, 10 children, and 8 patients with familial MF). In all, 44 samples were negative for HHV 8 DNA; two samples from adults with sporadic MF were positive. Limitations: The presence of HHV 8 antibodies or virus sequences was not assessed in peripheral blood. Conclusion: The results of this study, conducted in a region relatively endemic for HHV 8, support most earlier studies showing a lack of association of HHV 8 infection with LPP and sporadic adult-type MF. To our knowledge, the lack of association of HHV 8 infection with juvenile and familial MF has not been previously reported.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume66
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • familial
  • human herpesvirus 8
  • juvenile
  • lymphoma
  • mycosis fungoides
  • parapsoriasis
  • skin cancer

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