Human herpes virus 6 reactivation following autologous hematopoietic cell transplantation–a single-center experience

Liat Shargian-Alon, Dafna Yahav, Uri Rozovski, Sara Dovrat, Irina Amitai, Michal Sela-Navon, Oren Pasvolsky, Pia Raanani, Moshe Yeshurun

Research output: Contribution to journalArticlepeer-review

Abstract

Data regarding presentation and management of human herpes virus 6 (HHV-6) reactivation among autologous hematopoietic cell transplantation (HCT) recipients are limited. We retrospectively reviewed medical charts of all autologous HCT patients tested for HHV-6 reactivation due to suspected clinical presentation between 1/2012 and 8/2017. Among 328 autologous HCT recipients, 44 patients were tested for HHV-6 reactivation. Thirty patients tested positive; 29 (97%) had sustained fever, six (20%) had rash and four (13%) had pneumonia. Median C-reactive protein was significantly lower in HHV-6 positive patients compared to negative patients (3.6 (range, 0.4–11) vs. 9.6 (range, 3.2–30) mg/dL, respectively, p =.004). Ganciclovir formulations were administrated in 29 (97%) patients with median time to fever resolution of one (range, 1–2) day. HHV-6 should be considered as an important cause of post engraftment fever in autologous HCT. Larger studies are warranted to evaluate incidence of HHV-6 reactivation and optimal treatment regimen.

Original languageEnglish
Pages (from-to)2230-2236
Number of pages7
JournalLeukemia and Lymphoma
Volume60
Issue number9
DOIs
StatePublished - 29 Jul 2019

Keywords

  • Autologous
  • HHV-6
  • human herpes virus 6
  • transplantation

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