Human follicular nitric oxide pathway: Relationship to follicular size, oestradiol concentrations and ovarian blood flow

Eyal Y. Anteby, Arye Hurwitz, Osnat Korach, Ariel Revel, Alex Simon, Zvezdana Finci-Yeheskel, Michael Mayer, Neri Laufer

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) has been suggested to be involved in ovarian physiology. Our aim was to study follicular nitrite and nitrate (NO3/NO2) levels in women undergoing in-vitro fertilization (IVF), and to examine their relationship to follicular size, oestradiol concentrations, and ovarian artery and intra-ovarian blood flow as measured by Doppler ultrasound. A total of 15 patients from the IVF programme of Hadassah University Hospital, Mt Scopus, Israel, participated in the study. Detailed transvaginal ultrasonographic examination was performed before ovum collection, and ovarian artery and intra-ovarian blood flow were measured. While aspirating the follicles, the content of two to four of the follicles in each ovary was collected individually, the volume of follicular fluid measured, and NO3/NO2 concentrations were determined. A statistically significant positive correlation was found between follicular fluid NO3/NO2 concentrations and follicular volume (r = 0.76), as well as between NO3/NO2 concentrations and oestradiol concentrations (r = 0.63). A statistically significant negative correlation was found between follicular fluid NO3/NO2 concentrations and ovarian flow parameters as well as between NO3/NO2 concentrations in follicles containing 4-5 ml and ovarian artery pulsatility index.

Original languageEnglish
Pages (from-to)1947-1951
Number of pages5
JournalHuman Reproduction
Volume11
Issue number9
DOIs
StatePublished - Sep 1996
Externally publishedYes

Keywords

  • Blood flow
  • Nitric oxide
  • Nitrite:nitrate
  • Oestradiol
  • Ovarian follicle

Fingerprint

Dive into the research topics of 'Human follicular nitric oxide pathway: Relationship to follicular size, oestradiol concentrations and ovarian blood flow'. Together they form a unique fingerprint.

Cite this