Human DNA Topoisomerase II-α expression in laparoscopically treated renal cell carcinoma

Yoram Dekel; Thomas Frede; Valentina Kugel; Gad Neumann; Jens Rassweiler; Rumelia Koren

Human DNA Topoisomerase II-α expression in laparoscopically treated renal cell carcinoma

Yoram Dekel, Thomas Frede, Valentina Kugel, Gad Neumann, Jens Rassweiler, Rumelia Koren^*

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

To investigate whether the expression of Topoisomerase II-α (TII-α) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-α expression. The percentage of positive cells in the area of greatest staining was recorded as the TII-α index. TII-α nuclear staining was positive in all the samples except one. The mean TII-α index was 12.5 for grade 1, 44 for grade 2 and 113 for grade 3 tumors. The mean TII-α index was 22.3 in tumors which did not recur and 81 for tumors which recurred during the follow-up period. In this study, a higher TII-α index correlated with more aggressive tumor behaviour. However, a large cohort of patients should be assessed before drawing definitive conclusions.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Oncology Reports
Volume	14
Issue number	1
State	Published - Jul 2005

Keywords

Prognosis
Renal cell carcinoma
Survival
Topoisomerase II-α

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abstract = "To investigate whether the expression of Topoisomerase II-α (TII-α) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-α expression. The percentage of positive cells in the area of greatest staining was recorded as the TII-α index. TII-α nuclear staining was positive in all the samples except one. The mean TII-α index was 12.5 for grade 1, 44 for grade 2 and 113 for grade 3 tumors. The mean TII-α index was 22.3 in tumors which did not recur and 81 for tumors which recurred during the follow-up period. In this study, a higher TII-α index correlated with more aggressive tumor behaviour. However, a large cohort of patients should be assessed before drawing definitive conclusions.",

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T1 - Human DNA Topoisomerase II-α expression in laparoscopically treated renal cell carcinoma

AU - Dekel, Yoram

AU - Frede, Thomas

AU - Kugel, Valentina

AU - Neumann, Gad

AU - Rassweiler, Jens

AU - Koren, Rumelia

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AB - To investigate whether the expression of Topoisomerase II-α (TII-α) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-α expression. The percentage of positive cells in the area of greatest staining was recorded as the TII-α index. TII-α nuclear staining was positive in all the samples except one. The mean TII-α index was 12.5 for grade 1, 44 for grade 2 and 113 for grade 3 tumors. The mean TII-α index was 22.3 in tumors which did not recur and 81 for tumors which recurred during the follow-up period. In this study, a higher TII-α index correlated with more aggressive tumor behaviour. However, a large cohort of patients should be assessed before drawing definitive conclusions.

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KW - Renal cell carcinoma

KW - Survival

KW - Topoisomerase II-α

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Human DNA Topoisomerase II-α expression in laparoscopically treated renal cell carcinoma

Abstract

Keywords

UN SDGs

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