Human chorionic gonadotrophin and trisomy 18

G. Barkai; R. Chaki; M. Sochat; B. Goldman

doi:10.1002/ajmg.1320410115

Human chorionic gonadotrophin and trisomy 18

G. Barkai^*, R. Chaki, M. Sochat, B. Goldman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Estimation of maternal serum β-hCG is used in conjunction with α- fetoprotein (AFP) and estriol (E₃) for estimating the risk of Down syndrome (DS) affected fetuses. However, low hCG levels have not been regarded as having clinical significance. We report on 2 patients with trisomy 18 fetuses in whom antenatal screening showed extremely low hCG levels (0.05 and 0.15 MOM). Low hCG levels might indicate increased risk for trisomy 18 despite low estimated risk for DS.

Original language	English
Pages (from-to)	52-53
Number of pages	2
Journal	American Journal of Medical Genetics
Volume	41
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.1320410115
State	Published - 1991
Externally published	Yes

Keywords

low β-hCG
maternal serum
trisomy 18

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AU - Sochat, M.

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Human chorionic gonadotrophin and trisomy 18

Abstract

Keywords

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