Human chorionic gonadotrophin and trisomy 18

G. Barkai*, R. Chaki, M. Sochat, B. Goldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Estimation of maternal serum β-hCG is used in conjunction with α- fetoprotein (AFP) and estriol (E3) for estimating the risk of Down syndrome (DS) affected fetuses. However, low hCG levels have not been regarded as having clinical significance. We report on 2 patients with trisomy 18 fetuses in whom antenatal screening showed extremely low hCG levels (0.05 and 0.15 MOM). Low hCG levels might indicate increased risk for trisomy 18 despite low estimated risk for DS.

Original languageEnglish
Pages (from-to)52-53
Number of pages2
JournalAmerican Journal of Medical Genetics
Issue number1
StatePublished - 1991
Externally publishedYes


  • low β-hCG
  • maternal serum
  • trisomy 18


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