Human cerebral blood volume measurements using dynamic contrast enhancement in comparison to dynamic susceptibility contrast MRI

Moran Artzi, Gilad Liberman, Guy Nadav, Faina Vitinshtein, Deborah T. Blumenthal, Felix Bokstein, Orna Aizenstein, Dafna Ben Bashat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Cerebral blood volume (CBV) is an important parameter for the assessment of brain tumors, usually obtained using dynamic susceptibility contrast (DSC) MRI. However, this method often suffers from low spatial resolution and high sensitivity to susceptibility artifacts and usually does not take into account the effect of tissue permeability. The plasma volume (vp) can also be extracted from dynamic contrast enhancement (DCE) MRI. The aim of this study was to investigate whether DCE can be used for the measurement of cerebral blood volume in place of DSC for the assessment of patients with brain tumors. Methods: Twenty-eight subjects (17 healthy subjects and 11 patients with glioblastoma) were scanned using DCE and DSC. vp and CBV values were measured and compared in different brain components in healthy subjects and in the tumor area in patients. Results: Significant high correlations were detected between vp and CBV in healthy subjects in the different brain components; white matter, gray matter, and arteries, correlating with the known increased tissue vascularity, and within the tumor area in patients. Conclusion: This work proposes the use of DCE as an alternative method to DSC for the assessment of blood volume, given the advantages of its higher spatial resolution, its lower sensitivity to susceptibility artifacts, and its ability to provide additional information regarding tissue permeability.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
JournalNeuroradiology
Volume57
Issue number7
DOIs
StatePublished - 22 Jul 2015

Keywords

  • Brain tumor
  • Cerebral blood volume
  • Dynamic contrast enhancement
  • Dynamic susceptibility contrast
  • MRI

Fingerprint

Dive into the research topics of 'Human cerebral blood volume measurements using dynamic contrast enhancement in comparison to dynamic susceptibility contrast MRI'. Together they form a unique fingerprint.

Cite this