TY - JOUR
T1 - HTLV-1 in mouthwash cells from a TSP/HAM patient and asymptomatic carriers
AU - Offen, D.
AU - Achiron, A.
AU - Wasserman, L.
AU - Miller, M.
AU - Shaklai, M.
AU - Dabby, R.
AU - Gorodin, S.
AU - Shohat, B.
PY - 1998
Y1 - 1998
N2 - Using in situ hybridization, the presence of T-cell lymphotrophic virus type I (HTLV-I) was shown in blood lymphocytes of one tropical spastic paraparesis (TSP/HAM) patient and in two asymptomatic carriers. HTLV-I was also detected in epithelial cells derived from mouthwash of the TSP/HAM patient. Mouthwash of one of the carriers showed an infected lymphocyte while mouthwash of the other carrier was negative. The infected epithelial cells stained both in the nucleus and in the cytoplasm, which indicated the presence of the virus in both subcellular compartments. Our observations suggest that saliva cells, lymphocytes and epithelial cells, may potentially participate in oral transmission of HTLV-I.
AB - Using in situ hybridization, the presence of T-cell lymphotrophic virus type I (HTLV-I) was shown in blood lymphocytes of one tropical spastic paraparesis (TSP/HAM) patient and in two asymptomatic carriers. HTLV-I was also detected in epithelial cells derived from mouthwash of the TSP/HAM patient. Mouthwash of one of the carriers showed an infected lymphocyte while mouthwash of the other carrier was negative. The infected epithelial cells stained both in the nucleus and in the cytoplasm, which indicated the presence of the virus in both subcellular compartments. Our observations suggest that saliva cells, lymphocytes and epithelial cells, may potentially participate in oral transmission of HTLV-I.
UR - http://www.scopus.com/inward/record.url?scp=0031861395&partnerID=8YFLogxK
U2 - 10.1007/s007050050352
DO - 10.1007/s007050050352
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AN - SCOPUS:0031861395
SN - 0304-8608
VL - 143
SP - 1029
EP - 1034
JO - Archives of Virology
JF - Archives of Virology
IS - 5
ER -