TY - CHAP
T1 - H∞ Feedback Control Theory in Biochemical Systems
AU - Gershon, Eli
AU - Shaked, Uri
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019
Y1 - 2019
N2 - A new approach is presented for the study of H∞ optimal control of biochemical pathways. Starting with various linear models of single enzymatic reaction systems, a simple unbranched four-block enzyme system that contains a negative feedback loop is analyzed in the open- and the closed-loop configurations, where it is shown that the closed-loop configuration is one of the static output-feedback control systems. The original nonlinear four-block system is modeled as a polytopic-type uncertain linear system, where the extent of the nonlinearity can be “tuned” by a fictitious uncertainty interval, thus better capturing the nonlinear nature of the systems under study. The sensitivity of the latter enzymatic system to variations in certain variables is explored via the optimal H∞ control approach. Based on this approach, the threonine synthesis pathway that contains three negative feedback loops is analyzed and is shown to be optimal in the H∞ sense.
AB - A new approach is presented for the study of H∞ optimal control of biochemical pathways. Starting with various linear models of single enzymatic reaction systems, a simple unbranched four-block enzyme system that contains a negative feedback loop is analyzed in the open- and the closed-loop configurations, where it is shown that the closed-loop configuration is one of the static output-feedback control systems. The original nonlinear four-block system is modeled as a polytopic-type uncertain linear system, where the extent of the nonlinearity can be “tuned” by a fictitious uncertainty interval, thus better capturing the nonlinear nature of the systems under study. The sensitivity of the latter enzymatic system to variations in certain variables is explored via the optimal H∞ control approach. Based on this approach, the threonine synthesis pathway that contains three negative feedback loops is analyzed and is shown to be optimal in the H∞ sense.
UR - http://www.scopus.com/inward/record.url?scp=85066746011&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-16008-1_16
DO - 10.1007/978-3-030-16008-1_16
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.chapter???
AN - SCOPUS:85066746011
T3 - Lecture Notes in Control and Information Sciences
SP - 231
EP - 278
BT - Lecture Notes in Control and Information Sciences
PB - Springer Verlag
ER -