H feedback-control of the Threonine Synthesis pathway via system uncertainty

Eli Gershon, Oren Yokev, Uri Shaked

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

In this paper we consider the well studied Threonine Synthesis pathway in E. Coli, leading from Aspartate to the end product Threonine, via a complex five step mechanism. We linearize each step in the pathway around pre-chosen physiologically sound set points. We then assemble the (originally nonlinear) system as a linear uncertain polytopic one. We study the effect of negative feedback-loops that are internally exerted on the system by Threonine. We then probe the sensitivity of the system to variations in certain variables in order to asses the possible optimality of the system, in the H sense.

Original languageEnglish
Title of host publication2007 European Control Conference, ECC 2007
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3724-3731
Number of pages8
ISBN (Electronic)9783952417386
StatePublished - 2007
Event2007 9th European Control Conference, ECC 2007 - Kos, Greece
Duration: 2 Jul 20075 Jul 2007

Publication series

Name2007 European Control Conference, ECC 2007

Conference

Conference2007 9th European Control Conference, ECC 2007
Country/TerritoryGreece
CityKos
Period2/07/075/07/07

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