Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

Paolo De Los Rios, Pierre Goloubinoff

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Forceful unfolding by entropic pulling is the general mechanism by which Hsp70 and Hsp110 chaperones control the oligomeric states, structures and activities of cellular proteins.

Original languageEnglish
Pages (from-to)766-769
Number of pages4
JournalNature Structural and Molecular Biology
Volume23
Issue number9
DOIs
StatePublished - 1 Sep 2016
Externally publishedYes

Funding

FundersFunder number
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung156948

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