HsCRP levels: Measurement of airway inflammation in asthmatic children

Ruth Soferman; Miguel Glatstein; Yakov Sivan; Yosef Weisman

doi:10.1111/j.1442-200X.2007.02517.x

HsCRP levels: Measurement of airway inflammation in asthmatic children

Ruth Soferman^*, Miguel Glatstein, Yakov Sivan, Yosef Weisman

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: The inflammatory marker, high-sensitivity C-reactive protein (HsCRP), is known to be related to non-allergic asthma, obesity, cardiovascular disease and smoking in adults. The aim of the present study was to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children. Methods: HsCRP was measured in 63 asthmatic children aged 2-12 years. The measurements were performed in 37 children during an episode of acute exacerbation and in 42 children during remission. Results: HsCRP level (14.28 ± 8.45 mg/L) during exacerbation was significantly higher than the mean level (1.92 ± 3.16 mg/L) during remission (P < 0.0001), with the decrease being more prominent in children with a low body mass index percentile (P < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 s and high-sensitivity C-reactive protein values (P > 0.049). Conclusion: Elevated HsCRP levels were significantly associated with respiratory impairment in children.

Original language	English
Pages (from-to)	12-16
Number of pages	5
Journal	Pediatrics International
Volume	50
Issue number	1
DOIs	https://doi.org/10.1111/j.1442-200X.2007.02517.x
State	Published - Feb 2008

Keywords

Asthmatic children
BMI%
FEV
HsCRP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1442-200X.2007.02517.x

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title = "HsCRP levels: Measurement of airway inflammation in asthmatic children",

abstract = "Background: The inflammatory marker, high-sensitivity C-reactive protein (HsCRP), is known to be related to non-allergic asthma, obesity, cardiovascular disease and smoking in adults. The aim of the present study was to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children. Methods: HsCRP was measured in 63 asthmatic children aged 2-12 years. The measurements were performed in 37 children during an episode of acute exacerbation and in 42 children during remission. Results: HsCRP level (14.28 ± 8.45 mg/L) during exacerbation was significantly higher than the mean level (1.92 ± 3.16 mg/L) during remission (P < 0.0001), with the decrease being more prominent in children with a low body mass index percentile (P < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 s and high-sensitivity C-reactive protein values (P > 0.049). Conclusion: Elevated HsCRP levels were significantly associated with respiratory impairment in children.",

keywords = "Asthmatic children, BMI%, FEV, HsCRP",

author = "Ruth Soferman and Miguel Glatstein and Yakov Sivan and Yosef Weisman",

year = "2008",

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doi = "10.1111/j.1442-200X.2007.02517.x",

language = "אנגלית",

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AU - Glatstein, Miguel

AU - Sivan, Yakov

AU - Weisman, Yosef

PY - 2008/2

Y1 - 2008/2

N2 - Background: The inflammatory marker, high-sensitivity C-reactive protein (HsCRP), is known to be related to non-allergic asthma, obesity, cardiovascular disease and smoking in adults. The aim of the present study was to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children. Methods: HsCRP was measured in 63 asthmatic children aged 2-12 years. The measurements were performed in 37 children during an episode of acute exacerbation and in 42 children during remission. Results: HsCRP level (14.28 ± 8.45 mg/L) during exacerbation was significantly higher than the mean level (1.92 ± 3.16 mg/L) during remission (P < 0.0001), with the decrease being more prominent in children with a low body mass index percentile (P < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 s and high-sensitivity C-reactive protein values (P > 0.049). Conclusion: Elevated HsCRP levels were significantly associated with respiratory impairment in children.

AB - Background: The inflammatory marker, high-sensitivity C-reactive protein (HsCRP), is known to be related to non-allergic asthma, obesity, cardiovascular disease and smoking in adults. The aim of the present study was to determine whether HsCRP is related to respiratory symptoms and pulmonary function test findings in asthmatic children. Methods: HsCRP was measured in 63 asthmatic children aged 2-12 years. The measurements were performed in 37 children during an episode of acute exacerbation and in 42 children during remission. Results: HsCRP level (14.28 ± 8.45 mg/L) during exacerbation was significantly higher than the mean level (1.92 ± 3.16 mg/L) during remission (P < 0.0001), with the decrease being more prominent in children with a low body mass index percentile (P < 0.05). A reciprocal relationship was found between forced expiratory volume in 1 s and high-sensitivity C-reactive protein values (P > 0.049). Conclusion: Elevated HsCRP levels were significantly associated with respiratory impairment in children.

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KW - BMI%

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HsCRP levels: Measurement of airway inflammation in asthmatic children

Abstract

Keywords

UN SDGs

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