How do transcription factors select specific binding sites in the genome?

Yongping Pan, Chung Jung Tsai, Buyong Ma, Ruth Nussinov

Research output: Contribution to journalComment/debate

Abstract

How does a transcription factor select a specific DNA response element given the presence of degenerate sequences? To date, this question has largely been viewed from the standpoint of DNA sequence variability and transcription factor binding affinity under steady-state conditions. Here we propose that to address this problem, it is also necessary to account for fluctuating cellular conditions. These lead to dynamic changes in the ensemble of protein (and DNA) conformational states via allosteric effects.

Original languageEnglish
Pages (from-to)1118-1120
Number of pages3
JournalNature Structural and Molecular Biology
Volume16
Issue number11
DOIs
StatePublished - Nov 2009

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