Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

Pierre Bost, Amir Giladi, Yang Liu, Yanis Bendjelal, Gang Xu, Eyal David, Ronnie Blecher-Gonen, Merav Cohen, Chiara Medaglia, Hanjie Li, Aleksandra Deczkowska, Shuye Zhang, Benno Schwikowski*, Zheng Zhang*, Ido Amit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

350 Scopus citations

Abstract

A computational framework that allows for the identification and characterization of virus-infected cells as well as bystander cell responses reveals how SARS-CoV-2 alters the immune responses of patients.

Original languageEnglish
Pages (from-to)1475-1488.e12
JournalCell
Volume181
Issue number7
DOIs
StatePublished - 25 Jun 2020
Externally publishedYes

Funding

FundersFunder number
ERC-Cog724471-HemTree2.0
Helen and Martin Kimmel
NeuroMac DFG/TransregionalPA-1604 08459
Wolfson Foundation and Family Charitable Trust
Howard Hughes Medical Institute
Achelis Foundation
Melanoma Research Alliance509044
École Normale SupérieureANR-10-LABX-62-IBEID
Merck KGaA
Horizon 2020 Framework Programme724471
Chan Zuckerberg Initiative
Thompson Family Foundation
European Research Council
National Natural Science Foundation of China91442127, 81700540
Israel Science Foundation703/15

    Keywords

    • COVID-19
    • Viral-Track
    • single-cell RNA-seq
    • virus host interactions

    Fingerprint

    Dive into the research topics of 'Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients'. Together they form a unique fingerprint.

    Cite this