TY - JOUR
T1 - Hospital-acquired infective endocarditis
T2 - Should the definition be broadened?
AU - Ben-Ami, Ronen
AU - Giladi, Michael
AU - Carmeli, Yehuda
AU - Orni-Wasserlauf, Ruth
AU - Siegman-Igra, Yardena
PY - 2004/3/15
Y1 - 2004/3/15
N2 - Hospital-acquired infective endocarditis (IE) is a growing health-care problem. Hospital-acquired IE, according to the commonly used definition, is IE manifesting ≥72 h after admission to the hospital or within several weeks after a hospital-based invasive procedure. To assess the validity of this definition, we evaluated 87 episodes of IE, with special attention to recent hospitalizations. The incidence rate of IE in the 6-month period after discharge from the hospital was 27 cases per 100,000 person-years, compared with 1.1 cases per 100,000 person-years in a population with no recent hospitalizations. Furthermore, episodes of IE manifesting during this 6-month period were notable for a high proportion of typically hospital-acquired pathogens (26% vs. 0%; P = .001) and a low proportion of viridans streptococci (0% vs. 36%; P < .001), compared with community-acquired episodes that did not involve recent hospitalization. We conclude that characteristics of hospitalacquired IE extend to episodes arising within 6 months after discharge from the hospital and suggest that the definition of hospital-acquired IE be broadened to include these episodes.
AB - Hospital-acquired infective endocarditis (IE) is a growing health-care problem. Hospital-acquired IE, according to the commonly used definition, is IE manifesting ≥72 h after admission to the hospital or within several weeks after a hospital-based invasive procedure. To assess the validity of this definition, we evaluated 87 episodes of IE, with special attention to recent hospitalizations. The incidence rate of IE in the 6-month period after discharge from the hospital was 27 cases per 100,000 person-years, compared with 1.1 cases per 100,000 person-years in a population with no recent hospitalizations. Furthermore, episodes of IE manifesting during this 6-month period were notable for a high proportion of typically hospital-acquired pathogens (26% vs. 0%; P = .001) and a low proportion of viridans streptococci (0% vs. 36%; P < .001), compared with community-acquired episodes that did not involve recent hospitalization. We conclude that characteristics of hospitalacquired IE extend to episodes arising within 6 months after discharge from the hospital and suggest that the definition of hospital-acquired IE be broadened to include these episodes.
UR - http://www.scopus.com/inward/record.url?scp=1642402049&partnerID=8YFLogxK
U2 - 10.1086/381971
DO - 10.1086/381971
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AN - SCOPUS:1642402049
SN - 1058-4838
VL - 38
SP - 843
EP - 850
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 6
ER -